ASSOCIATION BETWEEN TRIGLYCERIDE–GLUCOSE INDEX AND LIVERFIBROSIS IN ADULTS WITH METABOLISM-RELATED FATTY LIVERDISEASE

Authors

  • B.B. Khojiev Author

DOI:

https://doi.org/10.5281/zenodo.20512072

Keywords:

TyG index, MAFLD, liver fibrosis, insulin resistance, elastography, metabolic syndrome

Abstract

Metabolism-related fatty liver disease (MAFLD) is a highly prevalent condition strongly associated with insulin resistance and metabolic syndrome. Liver fibrosis is the most important prognostic factor determining disease progression and long-term outcomes. The triglyceride–glucose (TyG) index is a simple and cost-effective surrogate marker of insulin resistance. Recent evidence suggests that the TyG index may be associated with liver fibrosis severity in MAFLD patients. This study aimed to evaluate the relationship between TyG index and liver fibrosis stages in adults with MAFLD using biochemical markers and noninvasive elastography.

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Published

2026-06-02

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Articles

References

1. Simental-Mendía LE et al. Triglyceride-glucose index as surrogate of insulin resistance. J Clin Endocrinol Metab. 2018.

2. Eslam M et al. MAFLD definition and clinical implications. J Hepatol. 2020.

3. Loomba R, Adams LA. Advances in NAFLD fibrosis assessment. Nat Rev Gastroenterol Hepatol. 2021.

4. Wang J et al. Diagnostic value of TyG index in fatty liver disease. Nutrients. 2022.

5. Zhang S et al. TyG index and NAFLD risk: meta-analysis. Front Endocrinol. 2022.

6. Lee SB et al. TyG index and liver fibrosis association. Clin Gastroenterol Hepatol. 2021.

7. European Association for the Study of the Liver (EASL). Clinical Practice Guidelines. 2021.

8. American Association for the Study of Liver Diseases (AASLD). Practice Guidance. 2022–2023.