Tibbiyot
Tuxtayeva Nigora Xasanovna
Karimov Ma’rif Shakirovich
Babajanov Xudoybergan Egamberdi o`g`li
10.5281/zenodo.18923255
Annotatsiya
Onkogenez — hujayralarning genetik va epigenetik o‘zgarishlari natijasida nazoratsiz proliferatsiyaga o‘tish jarayonidir. Jarayon protoonkogenlarning faollashuvi va o‘smani bostiruvchi genlarning inaktivatsiyasi bilan bog‘liq. DNK reparatsiya tizimidagi nuqsonlar genom beqarorligini kuchaytiradi. Epigenetik modifikatsiyalar gen ekspressiyasining buzilishiga olib keladi. O‘sma rivojlanishida hujayra sikli nazoratining yo‘qolishi muhim ahamiyatga ega. Apoptoz mexanizmlarining susayishi shikastlangan hujayralarning saqlanishiga sabab bo‘ladi. Metabolik qayta dasturlanish saraton hujayralarining energetik ehtiyojini ta’minlaydi.O‘sma mikroatrofi proliferatsiya va invaziyani qo‘llab-quvvatlaydi. Immun tizimdan qochish mexanizmlari o‘smaning barqarorligini oshiradi. Epitelial-mezenximal transformatsiya metastaz jarayonida muhim rol o‘ynaydi. Molekulyar profiling texnologiyalari individual xususiyatlarni aniqlash imkonini beradi. Onkogenezni chuqur o‘rganish erta diagnostika va maqsadli davolash strategiyalarini takomillashtirishga xizmat qiladi.
Kalit so'zlar:
Onkogenez, kanserogenez, mutatsiya, protoonkogen, onkogen, o‘smani bostiruvchi genlar, genom beqarorligi, DNK reparatsiyasi, epigenetik modifikatsiya, apoptoz, proliferatsiya,
Foydalanilgan adabiyotlar
1.Robert A. Weinberg — The Biology of Cancer (3-chi nashr, 2023) — 2.Handbook of Oncobiology: From Basic to Clinical Sciences — https://link.springer.com/referencework/10.1007/978-981-99-6263-1 3.Oncogene (ilmiy jurnal) — http://www.nature.com/onc 4.Annual Review of Cancer Biology (journal) — https://www.annualreviews.org/journal/cancerbio 5.James DeGregori — Adaptive Oncogenesis (Harvard University Press) — (Harvard Univ. Press) 6.Siddhartha Mukherjee — The Emperor of All Maladies. (University of California Press, 2013) — https://en.wikipedia.org/wiki/The_Emperor_of_All_Maladies 7.Jean-Pascal Capp va boshqalar — Evidence of epigenetic oncogenesis — https://arxiv.org/abs/2411.14130 8.Crit. Rev. Oncog. (Critical Reviews in Oncogenesis) — http://www.begellhouse.com/journals/439f422d0783386a 9.Onkologik kasalliklar haqida tushuncha — https://scientific jl.com/obr/article/view/7065 10.CRISPR/Cas9 texnologiyasi bilan saraton kasalligini davolash — 11. Nurmetov, H. T., Marufkhanov, H. M., Talipov, R. M., & Tukhtaeva, N. H. (2023). Clinical and epidemiological features of ankylosing spondylitis in a hospital setting. 12.Azadayeva, K. E., Tukhtayeva, N. Kh., & Karimov, M. Sh. (2023). Characteristics of the lipid profile of blood in patients with reactive arthritis with impaired gastro-duodenal microbiocenosis and ways to correct it. 13. Nurmetov, K. T., Marufkhanov, K. M., Talipov, R. M., & Tukhtaeva, N. K. (2023). Clinical and epidemiological features of ankylosing spondylitis in a hospital setting.
