- Sirdaryo viloyati Guliston shahar
- Dushanba-Shanba: 9.00 - 18.00
Makhamadaminova Shoira Abduvaliyevna
Narzullayev Jamshid Khamidovich
10.5281/zenodo.23074012
Annotatsiya
maqolada otorinolaringologik operatsiyalardan keyingi davrda trombotsitlarga boy plazma (Platelet-Rich Plasma, PRP) terapiyasidan foydalanishning klinik imkoniyatlari tahlil qilinadi. PRP bemorning o‘z qonidan olinadigan autolog biologik preparat bo‘lib, tarkibidagi trombotsitlar va o‘sish omillari to‘qimalarning regeneratsiyasi, angiogenez va epitelizatsiya jarayonlarini rag‘batlantirishda muhim ahamiyatga ega. Zamonaviy tadqiqotlarda PRP burun shilliq qavatining tiklanishini tezlashtirish, quruqlik va qobiq hosil bo‘lishini kamaytirish, endoskopik sinus operatsiyalaridan keyingi yallig‘lanish jarayonlarini nazorat qilish hamda timpanoplastikadan keyingi transplantat bitishini yaxshilash imkoniyatiga ega ekanligi ko‘rsatilgan. Shu bilan birga, PRPni tayyorlash va qo‘llash protokollarining turlicha bo‘lishi mavjud dalillarni umumlashtirishni qiyinlashtiradi.
Kalit so'zlar:
PRP, trombotsitlarga boy plazma, LOR jarrohligi, regeneratsiya, yara bitishi, burun shilliq qavati, endoskopik sinus jarrohligi, timpanoplastika.
Foydalanilgan adabiyotlar
1. Albazee E., Alabbas M., Alotaibi A. et al. Platelet-rich plasma following endoscopic sinus surgery in patients with chronic sinusitis: A systematic review and meta-analysis of randomised controlled trials // Clinical Otolaryngology. 2024. DOI: 10.1111/coa.14186. 2. Clinical Outcomes of Platelet-Rich Plasma in Otology: A Systematic Review of Tympanoplasty, Myringoplasty, and Hearing Loss Management. 2026. 3. Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis // BMC Ear, Nose and Throat Disorders. 2021. 4. Handoko R.E., Fitri L.E., Reksodiputro M.H. et al. Enhancing wound healing in otorhinolaryngology with autologous platelet concentrates: a systematic review of clinical outcomes // The Journal of Laryngology & Otology. 2026. Vol. 140, No. 4. P. 346-352. DOI: 10.1017/S0022215126104320. 5. Pakpattaraphaiboon P., Jitaroon K., Limpornpugdee S. Efficacy of Platelet-Rich Plasma (PRP) on Post-Surgical Outcomes Following Endoscopic Frontal Sinusotomy: A Randomised Controlled Trial // Clinical Otolaryngology. 2026. Vol. 51, No. 2. P. 296-306. DOI: 10.1111/coa.70062.