- Sirdaryo viloyati Guliston shahar
- Dushanba-Shanba: 9.00 - 18.00
Shodiyev Murodali Erkinovich
Mirsobitova Dilsora Mirakbarovna
Gulmonov Hakimjon Shukurullo o‘g‘li
10.5281/zenodo.21062192
Annotatsiya
Zamonaviy toksikologik kimyoda biologik namunalarda zaharli
moddalarni aniqlash inson salomatligini muhofaza qilish, zaharlanish holatlariga tezkor
tashxis qo‘yish hamda sud-tibbiy ekspertiza jarayonlarini ishonchli dalillar bilan
ta’minlashda muhim o‘rin tutadi. Biologik obyektlar tarkibida toksik moddalar ko‘pincha
juda past konsentratsiyalarda uchrashi sababli yuqori sezgirlik, selektivlik va aniqlikka
ega analitik usullardan foydalanish talab etiladi. Mazkur maqolada toksikologik kimyoda
keng qo‘llanilayotgan gaz xromatografiyasi, yuqori samarali suyuqlik xromatografiyasi,
xromatografiya-mass-spektrometriya, atom-absorbsiya spektrometriyasi, induktiv
bog‘langan plazmali mass-spektrometriya hamda immunokimyoviy tahlil usullarining
imkoniyatlari tahlil qilindi. Shuningdek, biologik namunalarga dastlabki ishlov berish
bosqichlari, analitik natijalarning ishonchliligiga ta’sir etuvchi omillar hamda laboratoriya
diagnostikasida zamonaviy texnologiyalarni joriy etish istiqbollari yoritildi. Tadqiqot
natijalari toksikologik tahlilning samaradorligini oshirishda kompleks analitik yondashuv
muhim ahamiyat kasb etishini ko‘rsatadi.
Kalit so'zlar:
toksikologik kimyo, biologik namuna, zaharli moddalar, HPLC, GC-MS,
LC-MS/MS, ICP-MS, sud-tibbiy toksikologiya, analitik kimyo, laborator diagnostika.
Foydalanilgan adabiyotlar
1. World Health Organization. Guidelines for Poison Control. Geneva: WHO;
2021.
2. World Health Organization. The WHO Model List of Essential In Vitro
Diagnostics. Geneva: WHO; 2023.
3. United Nations Office on Drugs and Crime (UNODC). Recommended Methods
for the Identification and Analysis of Drugs. Vienna: UNODC; 2022.
4. Clarke’s Analysis of Drugs and Poisons. 5th ed. London: Pharmaceutical Press;
2021.
5. Levine B. Principles of Forensic Toxicology. 5th ed. Springer; 2020.
6. Baselt R.C. Disposition of Toxic Drugs and Chemicals in Man. 12th ed.
Biomedical Publications; 2020.
7. Burtis C.A., Bruns D.E. Tietz Fundamentals of Clinical Chemistry and
Molecular Diagnostics. 8th ed. Elsevier; 2019.
8. Skoog D.A., Holler F.J., Crouch S.R. Principles of Instrumental Analysis. 7th
ed. Cengage Learning.
9. Harris D.C. Quantitative Chemical Analysis. 10th ed. W.H. Freeman.
10. Christian G.D. Analytical Chemistry. 7th ed. Wiley.
11. Snyder L.R., Kirkland J.J., Dolan J.W. Introduction to Modern Liquid
Chromatography. Wiley.
12. Miller J.N., Miller J.C. Statistics and Chemometrics for Analytical Chemistry.
Pearson.
13. Farmakopeya Respublikasi O’zbekiston. Toshkent, oxirgi nashr.