tafakkur manziliAnnotatsiya
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder strongly associated with central obesity and insulin resistance (IR). Recently, cholecystectomy has also been suggested as a potential risk factor for NAFLD due to alterations in bile acid metabolism and lipid homeostasis. However, its independent contribution compared with well established drivers such as visceral obesity and insulin resistance remains controversial. This review summarizes current evidence on the relative roles of cholecystectomy, central obesity, and insulin resistance in the development of NAFLD.
Kalit so'zlar:
NAFLD is the most common chronic liver disease worldwide, affecting approximately one-quarter of the adult population. Its pathogenesis is multifactorial, but central obesity and insulin resistance are recognized as core mechanisms.
Foydalanilgan adabiyotlar
1. Younossi ZM et al. Global epidemiology of NAFLD. Hepatology. 2020–2021 updates. 2. Eslam M, Newsome PN, et al. MAFLD concept and metabolic drivers. J Hepatol. 2020. 3. Loomba R, Adams LA. Advances in NAFLD pathogenesis. Nat Rev Gastroenterol Hepatol. 2021. 4. Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2018–2021. 5. Chiang JYL. Bile acid signaling in metabolic disease. Hepatology. 2020. 6. Hofmann AF. Bile acids and metabolic regulation. Gastroenterology. 2019. 7. Meta-analyses on cholecystectomy and NAFLD risk. Clin Gastroenterol Hepatol. 2022. 8. Zhang Y et al. Association between cholecystectomy and fatty liver disease: systematic review. BMC Gastroenterology. 2023. 9. Lonardo A et al. Obesity and NAFLD pathogenesis. Metabolism. 2019. 10. Tilg H, Effenberger M. Insulin resistance and fatty liver disease. Hepatology. 2020.
