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HISTORY OF HORMONE REPLACEMENT THERAPY IN HYPOTHYROIDISM

Avtorlar: Negmatova Gulzoda Shuhratovna, Oybutayeva Nargiza Ulugbek qizi
Kategoriya (Jurnal/Konferensiya): Tafakkur manzili
Sana: 2025-12-20

Annotatsiya

120 years ago, hormonal replacement therapy began to be used to treat hypothyroidism.
The first drug was thyroid extract, which was administered intramuscularly by G. Murray
in 1891, and was later developed for oral use a year later.

Kalit so‘zlar

converted to triiodothyronine in the periphery

Foydalanilgan adabiyotlar

1.Ferretti E., Persani L., Jaffrain-Rea ML., Giambona S.,et al. // Evalution of the
adequacy of levothyroxine replacement therapy in patients with central hypothyroidism. J
Clin Endocrinol Metab. 1999 Mar;84(3):924-929
2.Biondi B, Wartofsky L.// Treatment with thyroid hormone.//Endocr Rev. 2014
Jun;35(3):433-512.
3.Boelaert K, Newby P.R., Simmonds M.J. et al. // Prevalence and relative risk of other
autoimmune diseases in subjects with autoimmune thyroid disease. Am. J. Med. 2010;
123, 183.e1–e9.
4.Bunevičius R., Jakubonien N., Cernicat J., Laas L., et al. // Thyroxine vs
thyroxine plus triiodothyronine in treatment of hypothyroidism after
thyroidectomy for Grave’s disease. // Endocrine. 2002; Vol. 18, N 2. – P. 129-134.

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