ASSOCIATION OF THE AR RS6624304 POLYMORPHISM WITH THE RISK OF POLYCYSTIC OVARY SYNDROME IN WOMEN OF REPRODUCTIVE AGE

Abstract

Ovarian hyperandrogenism in women of reproductive age represents one of the key

pathogenetic components of polycystic ovary syndrome (PCOS), a multifactorial endocrine

disorder characterized by ovulatory dysfunction, androgen excess, and metabolic

disturbances. This phenotype is associated with dysregulated steroidogenesis in ovarian

theca cells and reduced peripheral tissue sensitivity to insulin and steroid hormones (Franks

et al., 2008; Goodarzi et al., 2011).