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Cyclodextrin in drug medication
Annotatsiya
Cyclodextrin molecules (CDs) are useful excipients in pharmacology in this day
and age. The main interest in CDs was gained due to their ability to interact with
hydrophobic molecules, increasing solubility in water. The high solubility is the result of
complexation through non-covalent bonding, as well as the formation of aggregates. This
review intends to give general knowledge about CDs’ shape and structure. Discuss the effect
of both host (CDs and their derivatives) and guest (drugs) molecules on complex formation.
Further part covers the application of CD-based drugs to pharmacology. As a result of this
review, the author believes that CDs will be modified to deliver complex molecules to treat
crucial diseases in the near future
Kalit so‘zlar
Cyclodextrin, hydrophobic molecules, solubility, aggregates.
Foydalanilgan adabiyotlar
13. Schönbeck, C. (2018). Charge determines guest orientation: a combined NMR and
molecular dynamics study of β-cyclodextrins and adamantane derivatives. The
Journal of Physical Chemistry B, 122(18), 4821-4827.
14. Béni, S., Szakács, Z., Csernák, O., Barcza, L., & Noszál, B. (2007).
Cyclodextrin/imatinib complexation: binding mode and charge dependent
stabilities. european journal of pharmaceutical sciences, 30(2), 167-174.
15. Buvári, A., & Barcza, L. (1988). Complex formation of phenol, aniline, and their nitro
derivatives with β-cyclodextrin. Journal of the Chemical Society, Perkin
Transactions 2, (4), 543-545.
16. Cai, W., Yu, Y., & Shao, X. (2006). Studies on the interaction of α-cyclodextrin with
phospholipid by a flexible docking algorithm. Chemometrics and intelligent
laboratory systems, 82(1-2), 260-268.
17. Wenz, G. (2000). An overview of host-guest chemistry and its application to
nonsteroidal anti-inflammatory drugs. Clinical Drug Investigation, 19(Suppl 2), 21
25.
18. Woodcock, B. G., Acerhiji, D., Merz, P. G., Riethrock, S., & Riethrock, N. (1993).
Supermolecular inclusion of piroxicam with b-cyclodextrin: pharmacokinetic
properties in man. European Journal of Rheumatology and fnflammation
Volume, 12(4).