- Sirdaryo viloyati Guliston shahar
- Dushanba-Shanba: 9.00 - 18.00
ASSOCIATION OF THE AR RS6624304 POLYMORPHISM WITH THE RISK OF POLYCYSTIC OVARY SYNDROME IN WOMEN OF REPRODUCTIVE AGE
Annotatsiya
Ovarian hyperandrogenism in women of reproductive age represents one of the key
pathogenetic components of polycystic ovary syndrome (PCOS), a multifactorial endocrine
disorder characterized by ovulatory dysfunction, androgen excess, and metabolic
disturbances. This phenotype is associated with dysregulated steroidogenesis in ovarian
theca cells and reduced peripheral tissue sensitivity to insulin and steroid hormones (Franks
et al., 2008; Goodarzi et al., 2011).
Kalit so‘zlar
testosterone or dihydrotestosterone triggers
Foydalanilgan adabiyotlar
The AR rs6624304 polymorphism was associated with the risk of PCOS.
The T allele and the C/T and T/T genotypes were linked to increased likelihood of
hyperandrogenic phenotypes, whereas the C/C genotype displayed a protective pattern and
was associated with more favorable hormonal and metabolic characteristics. These findings
support consideration of AR rs6624304 as a functionally relevant marker that may influence
regulation of AR expression and contribute to individual susceptibility to PCOS.