PODAGRA KECHISHIDA KOMORBID PATOLOGIYALARNING PATOGENETIK VA KLINIK XUSUSIYATLARI
DOI:
https://doi.org/10.5281/zenodo.22938815Ключевые слова:
Medikamentoz terapiya, podagra, giperurikemiya, metabolik kasalliklar, siydik kislotasiАннотация
Podagra — dunyoda eng keng tarqalgan yallig‘lanishli artrit bo‘lib, global sog‘liqni saqlash muammosining o‘sib borayotgan shaklidir. U purin almashinuvi buzilishi natijasida yuzaga kelgan giperurikemiya tufayli rivojlanadi, bu esa mononatriy urat (MNU) kristallarining cho‘kishi va takrorlanuvchi yallig‘lanishli artritga olib keladi. Giperurikemiya asosiy xavf omili bo‘lsa-da, genetik moyillik, urat transportining buzilishi va ichak mikrobiotasi kabi yangi omillar ham kasallik rivojlanishiga hissa qo‘shadi. O‘tkir zo‘rayishlar MNU kristallari tomonidan chaqirilgan NLRP3 inflammasomasining faollashuvi va keyinchalik interleykin-1β ishlab chiqarilishi orqali amalga oshadi, surunkali yallig‘lanish esa tofuslar hosil bo‘lishi va bo‘g‘imlarning strukturaviy shikastlanishiga olib keladi. Podagra metabolik sindrom, surunkali buyrak kasalligi va yurak-qon tomir kasalliklari bilan chambarchas bog‘liq bo‘lib, ular doimiy ravishda oshgan o‘limga hissa qo‘shadi. Vizualizatsiya va farmakologik terapiya sohasidagi yutuqlar tashxis va davolashni yaxshilagan bo‘lsa-da, urat pasaytiruvchi terapiyaning real amaliyotda qo‘llanilishi hali ham optimal emas. Kasallikni uzoq muddatli nazorat qilishni yaxshilash uchun qo‘shimcha tadqiqotlar va tibbiyot xodimlarining doimiy sa’y-harakatlari zarur.
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