PRP THERAPY AFTER ENT OPERATIONS: CURRENT EVIDENCE AND CLINICAL PERSPECTIVES

Аннотация

Platelet-rich plasma (PRP) therapy has recently attracted increasing attention as an adjunctive regenerative treatment in otorhinolaryngology. PRP is an autologous blood-derived product containing a high concentration of platelets and biologically active growth factors that may stimulate tissue repair, angiogenesis, epithelialization, and extracellular matrix remodeling. The postoperative period following ear, nose, and throat (ENT) surgery is often associated with inflammation, mucosal edema, crust formation, pain, delayed epithelialization, and impaired tissue regeneration. Therefore, the use of PRP may provide additional biological support for postoperative healing. This article reviews current evidence concerning the application of PRP after nasal surgery, endoscopic sinus surgery, myringoplasty, and tympanoplasty. Recent randomized clinical trials have demonstrated beneficial effects of PRP on nasal mucosal healing, postoperative crusting, nasal obstruction, and selected wound-healing parameters. Systematic reviews and meta-analyses have also reported improved tympanic membrane closure and graft uptake following PRP-assisted otologic surgery. However, considerable heterogeneity exists regarding PRP preparation, platelet concentration, activation methods, application techniques, and treatment protocols. Therefore, further well-designed randomized controlled trials and standardized clinical protocols are required before PRP can be routinely incorporated into postoperative ENT care.